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ADC Cytotoxin

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ADC Cytotoxin Isoform Comparison

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15142

Doxorubicin hydrochloride		99.90%
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.

HY-14648

Dexamethasone		99.86%
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research.

HY-B0015

Paclitaxel		99.97%
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.

HY-15162

Monomethyl auristatin E		99.97%
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

HY-13631A

Exatecan mesylate		99.97%
Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research.

HY-13631AS

Exatecan-d₅ mesylate		99.82%
c is deuterium labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research.

HY-159783

Mal-Exatecan
Mal-Exatecan is a Mal (Maleimide) modified Exatecan (HY-13631), a DNA topoisomerase I (topoisomerase I) inhibitor.

HY-164860

Glucocorticoid receptor agonist-5		99.95%
Glucocorticoid receptor agonist-5 (compound 4), a glucocorticoid molecule, is a potent glucocorticoid receptor agonist. Glucocorticoid receptor agonist-5 shows anti-inflammatory and immunosuppressive activity. Glucocorticoid receptor agonist-5 is used as an ADC Cytotoxin for antibody-drug conjugate.

HY-13631D

Dxd		99.43%
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC₅₀ of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).

HY-13704

SN-38		99.89%
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).

HY-14519

Methotrexate		99.87%
Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia).

HY-16560

Camptothecin		99.86%
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.

HY-13631

Exatecan		99.93%
Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL), and can be used in cancer research.

HY-19792

Mertansine		99.80%
Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).

HY-15579

MMAF		99.92%
MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A.

HY-13062

Daunorubicin hydrochloride		99.67%
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.

HY-42487

Exatecan Intermediate 1		99.99%
Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects.

HY-19610

α-Amanitin		99.92%
α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.

HY-13442

Eribulin		99.92%
Eribulin (E7389) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

HY-12454

DM4		99.64%
DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.

Toxins for Antibody-Drug Conjugate Research Library

Compound library containing all kinds of cytotoxins involved in the synthesis of ADC drugs.

113compounds HY-L023

Doxorubicin hydrochloride				Daunorubicins/Doxorubicins					99.90%
Paclitaxel								Traditional Cytotoxic Agents	99.97%
Monomethyl auristatin E	Auristatin								99.97%
Exatecan mesylate			Camptothecins						99.97%
Exatecan-d₅ mesylate			Camptothecins						99.82%
Glucocorticoid receptor agonist-5								Traditional Cytotoxic Agents	99.95%
Dxd			Camptothecins						99.43%
SN-38			Camptothecins						99.89%
Methotrexate								Traditional Cytotoxic Agents	99.87%
Camptothecin			Camptothecins						99.86%
Exatecan			Camptothecins						99.93%
Mertansine						Maytansinoids			99.80%
MMAF	Auristatin								99.92%
Daunorubicin hydrochloride				Daunorubicins/Doxorubicins					99.67%
Exatecan Intermediate 1			Camptothecins						99.99%
α-Amanitin								Traditional Cytotoxic Agents	99.92%
MMAE-d₈	Auristatin								99.29%
Calicheamicin		Calicheamicins							98.28%
Methotrexate disodium								Traditional Cytotoxic Agents	99.71%
Exatecan Intermediate 2			Camptothecins						99.99%
SG3199							Pyrrolobenzodiazepines		98.94%
PNU-159682				Daunorubicins/Doxorubicins					98.25%
(4-NH2)-Exatecan			Camptothecins						99.93%
Aldoxorubicin				Daunorubicins/Doxorubicins
Auristatin E	Auristatin								99.82%
Duocarmycin DM free base				Daunorubicins/Doxorubicins					99.69%
Exatecan Intermediate 6			Camptothecins						98.92%
SJG-136							Pyrrolobenzodiazepines		99.47%
MMAF hydrochloride	Auristatin								99.93%
Ansamitocin P-3						Maytansinoids			≥98.0%
Taltobulin								Traditional Cytotoxic Agents	99.90%
PF-06380101	Auristatin								99.47%
Exatecan (mesylate) (GMP)			Camptothecins
(R)-Exatecan Intermediate 1			Camptothecins						99.96%
Duocarmycin TM					Duocarmycins				98.04%
SG2057							Pyrrolobenzodiazepines		99.93%
Cyclopropaneacetamide-Exatecan			Camptothecins						99.60%
(1R,9R)-Exatecan mesylate			Camptothecins						99.94%
Duocarmycin SA					Duocarmycins				99.55%
MMAF-OMe	Auristatin								99.62%
(1S,9R)-Exatecan mesylate			Camptothecins						98.23%
Tubulysin A								Traditional Cytotoxic Agents	99.08%
Dolastatin 10	Auristatin								98.11%
Ac-Exatecan			Camptothecins						98.70%
MMAD	Auristatin								99.66%
β-Amanitin								Traditional Cytotoxic Agents
Daun02				Daunorubicins/Doxorubicins					98.72%
DM1-SMe						Maytansinoids			98.16%
Fmoc-MMAE	Auristatin								99.20%
(αR)-Cyclopropaneacetamide-Exatecan			Camptothecins						99.75%
N-Me-L-Ala-maytansinol						Maytansinoids			99.89%
MMAF sodium	Auristatin								99.59%
Hemiasterlin							Pyrrolobenzodiazepines		99.77%
Exatecan Intermediate 5			Camptothecins						99.98%
MMAF-d₈ hydrochloride	Auristatin								99.70%
DM4-SMe						Maytansinoids			99.99%
γ-Amanitin								Traditional Cytotoxic Agents
Duocarmycin GA					Duocarmycins				99.00%
Tomaymycin DM							Pyrrolobenzodiazepines		98.01%
DC0-NH2					Duocarmycins
10-Deacetyl-7-xylosyl paclitaxel								Traditional Cytotoxic Agents	99.65%
Exatecan Intermediate 7			Camptothecins						99.24%
DM3						Maytansinoids
Exatecan-methylacetamide-OH			Camptothecins
Exatecan-amide-cyclopropanol			Camptothecins						98.57%
PNU-159682 carboxylic acid				Daunorubicins/Doxorubicins
Decyclohexanamine-Exatecan			Camptothecins						98.38%
Exatecan analog 36			Camptothecins						98.71%
Exatecan intermediate 9			Camptothecins						99.80%
Exatecan Intermediate 4			Camptothecins
PF-06380101-d₈	Auristatin								99.37%
Doxorubicin				Daunorubicins/Doxorubicins
DC1SMe					Duocarmycins				≥98.0%
Daunorubicin				Daunorubicins/Doxorubicins
Duocarmycin Analog					Duocarmycins
Maytansinoid DM4						Maytansinoids
S-methyl DM1						Maytansinoids			99.58%
7-MAD-MDCPT			Camptothecins						98.00%
Taltobulin hydrochloride								Traditional Cytotoxic Agents	99.34%
Exatecan intermediate 10			Camptothecins						99.92%
Taltobulin trifluoroacetate								Traditional Cytotoxic Agents	99.08%
Exatecan Intermediate 4 dihydrochloride			Camptothecins						99.92%
Exatecan Intermediate 2 hydrochloride			Camptothecins						99.94%
(rac)-Exatecan Intermediate 1			Camptothecins						99.84%
Exatecan mesylate dihydrate			Camptothecins
Duocarmycin A					Duocarmycins
C-11								Traditional Cytotoxic Agents
DC1					Duocarmycins
(+)-CBI-CDPI1					Duocarmycins
DM3-SMe						Maytansinoids
Seco-Duocarmycin SA					Duocarmycins
DMEA-PNU-159682				Daunorubicins/Doxorubicins
DC41SMe					Duocarmycins
(+)-CBI-CDPI2					Duocarmycins
Duocarmycin MB					Duocarmycins
DC41					Duocarmycins
DC4SMe					Duocarmycins
Duocarmycin DM				Daunorubicins/Doxorubicins
Seco-Duocarmycin TM					Duocarmycins
Methotrexate monohydrate								Traditional Cytotoxic Agents
Aniline-MPB-amino-C3-PBD							Pyrrolobenzodiazepines
Rebeccamycin								Traditional Cytotoxic Agents
DC10SMe					Duocarmycins
Daunorubicin citrate				Daunorubicins/Doxorubicins
Dolastatin 15	Auristatin
Isofistularin-3								Traditional Cytotoxic Agents
ε-Amanitin								Traditional Cytotoxic Agents
Gly-Cyclopropane-Exatecan			Camptothecins
Mensacarcin								Traditional Cytotoxic Agents
Tubulysin IM-2								Traditional Cytotoxic Agents
Py-MPB-amino-C3-PBD							Pyrrolobenzodiazepines
Dimethyl-SGD-1882							Pyrrolobenzodiazepines
Top1 inhibitor 1			Camptothecins
Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol			Camptothecins
Tubulysin IM-3								Traditional Cytotoxic Agents
Exatecan-amide-bicyclo[1.1.1]pentan-1-ol			Camptothecins
MMAD-d₈	Auristatin								98.95%
17-AEP-GA								Traditional Cytotoxic Agents
(5-Cl)-Exatecan			Camptothecins
Polyketomycin								Traditional Cytotoxic Agents
Azonafide-PEABA								Traditional Cytotoxic Agents
(1-OH)-Exatecan			Camptothecins
Duocarmycin MA					Duocarmycins
17-GMB-APA-GA								Traditional Cytotoxic Agents
Exatecan analogue 1			Camptothecins
NH2-methylpropanamide-Exatecan TFA			Camptothecins						99.80%
Tubulysin IM-1								Traditional Cytotoxic Agents
Corixetan								Traditional Cytotoxic Agents
Sandramycin								Traditional Cytotoxic Agents
Exatecan intermediate 11			Camptothecins
Exatecan intermediate 8			Camptothecins
Exatecan Intermediate 3			Camptothecins
Exatecan-amide-CH2-O-CH2-CH2-OH			Camptothecins

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ADC Cytotoxin

ADC Cytotoxin

ADC Cytotoxin Isoform Specific Products:

ADC Cytotoxin Isoform Specific Products:

ADC Cytotoxin Related Products (304)

Antibodies (2)

Related Compound Screening Libraries (1)

ADC Cytotoxin Isoform Comparison

ADC Cytotoxin Related Products (304):